Breast Cancer : Overview, Causes, Symptoms, Risk factor, Treatment and Diagnosis

Breast cancer starts when cells in the breast begin to grow out of control. These cells usually form a tumor that can often be seen on an x-ray or felt as a lump. The tumor is malignant (cancer) if the cells can grow into (invade) Overview of breast cancer- Breast cancer occurs when cell of breast began to grow out of control often from a tumor which can start from a lump. The tumor occurs malignant when the cells grow in the surrounding tissue, i.e spread in the different parts of the body. The cancer can start in all part of the breast, but most cancers start in the inner lining of the milk ducts or globules that supply them with milk, rarely cancer start is the tissue of the breast. Breast cancer is the most common cause of cancer in women, men can also have breast cancer but it's rare (2000 new cases registered every year in US). It accounts for 16% of all female cancers, and 22.4% of invasive cancer worldwide, and 18.2% of all cancer deaths worldwide. One in every eight women in US has breast cancer.

Symptoms:

Symptoms of breast cancer- Any women having certain symptoms mentioned below should be consulted with a doctor immediately: A lump in a breast A pain in the armpits or breast that does not seem to be related to the woman's menstrual period Pitting or redness of the skin of the breast like the skin of an orange A rash around (or on) one of the nipples A swelling (lump) in one of the armpits An area of thickened tissue in a breast One of the nipples has a discharge sometimes it may contain blood The nipple changes in appearance it may become sunken or inverted The size or the shape of the breast changes The nipple-skin or breast-skin may have started to peel, scale or flake Causes of breast cancer- The cause of breast cancer is still not known. In breast cancer, the normal cells become cancerous through the mutation of cell DNA although some can be inherited but most cases occur that DNA changes related to breasts cancer occur during one's lifetime. Proto-oncogenes can also help, if these cells mutate the growth of any cell goes out of control.So, it can lead to cancer. Risk factors of breast cancer- Though the causes of breast cancer is not known there are some factors which can increase the chance of getting breast cancer such as: Age: The chances of getting breast cancer increases with the age of a person. Family history: The risk of breast cancer is higher among women who have relatives with the disease. Having a close relative increases the risk to double. Personal history: Women who had a breast cancer before, even a non-invasive one has a higher chance of getting breast cancer in the other breast. Menstruation: Women who started their menstrual cycle at a younger age (before 12) or went through menopause later (after 55) have a slightly increased risk. Breast tissue: Women with dense breast tissue (as documented by mammogram) have a higher risk of getting breast cancer. Race: White women have a higher risk of developing breast cancer. But African-American women have more proliferative and invasive tumors when they have them. Radiation-Exposure to previous chest radiation or use of diethylstilbestrol increases the risk of breast cancer. Having no children or the first child after age 30 increases the risk of breast cancer. Breastfeeding for one and a half to two years might slightly lower the risk of breast cancer. Being overweight or obese increases the risk of breast cancer. High sugar intake can increase the risk of breasts cancer. Use of oral contraceptives in the last 10 years increases the risk of breast cancer. Using combined hormone therapy after menopause increases the risk of breast cancer. Alcohol use increases the risk of breast cancer. Genetic risk factors: The most common causes are mutations in the BRCA1 and BRCA2 genes (breast cancer genes). Inheriting a mutated gene from a parent means that one has a significantly higher risk of developing breast cancer. Diagnosis of breast cancer- Mammogram-Mammogram is the X-ray of breast which is used to detect any abnormalities or changes in the breast. Women of higher age i.e. above 45 should undergo mammogram annually to detect any risk, or women of lower that age and higher that age must undergo mammogram to fall out the risk. Breast test-A test is done by the physician who looks for lump or any abnormalities in the breast which can indicate cancer. Ultrasound of breast-Ultrasound of a breast is done to look for dense breast tissues, or certain changes in the breast which can be felt but not seen in mammogram. MRI of breast-This technique is useful for women who had already detected with breast cancer. It helps to measure the size of the cancer, other tumors in breast and check for tumor in other breast. Breast biopsy-Biopsy of the breast is done, by taking a small tissue sample from the breast and studies it to find any abnormal or different cells in the breast tissue.

Treatments:

Treatments of breast cancer- The treatment of breast cancer take into account several factors of patient before starting the treatment such as the stage of the cancer, the health of the patient, the` age of the patient and also the type of the breast cancer. Surgery: Breast-conserving surgery (lumpectomy) - Only the part of the breast containing the cancer is removed along with some surrounding tissue. The removal of the breast tissue size depends on the size and location of the tumor. Mastectomy -In this surgery the entire breast is removed, including all of the breast tissue and sometimes other nearby tissues. Some women may also get a double mastectomy, in which both breasts are removed. If the cancer has passed on to the nearby lymph nodes than certain lymph node surgery is needed for the removal. Sentinel lymph node biopsy (SLNB) - In this method only the lymph nodes under the arm to which the cancer would likely to spread is removed. Axillary lymph node dissection (ALND) -In this method anywhere from about 10 to 40 (though usually less than 20) lymph nodes from under the arm. This technique is avoided as removal of such many lymph nodes can cause serious side effects. Radiation therapy: Breast radiation therapy - after a lumpectomy, radiation is administered to the remaining breast tissue to ensure no return of cancer. Chest wall radiation therapy - this is applied after a mastectomy to the chest walls or places where any drains which excited the body after surgery. Breast boost - a high-dose of radiation therapy is given after lumpectomy to the whole breast. Lymph nodes radiation therapy - the radiation is aimed at the axilla (armpit) and surrounding area to destroy cancer cells that have reached the lymph nodes Breast Brachytheraphy- All the previous radiation methods are external methos, i.e a radiation is provided from outside the body. In brachytherapy small device containing radioactive pellets is placed in the breast tissue for few minutes a radiation is given internally. They ensure targeted radiation to specific cancer cells and removal of them. Side effects of any radiation therapy may include irritation in breast region, redness, infection, fatigue and darkening of breast skin. Chemotherapy: Chemotherapy treatment can be given before or after radiation. Before radiation it is given to shrink the cancer size so less or no radiation is required. And after surgery it is given to remove any cancer cells which are remained back. Drugs used are: Anthracyclines, such as doxorubicin (Adriamycin) and epirubicin (Ellence) Taxanes, such as paclitaxel (Taxol) and docetaxel (Taxotere) 5-fluorouracil (5-FU) Cyclophosphamide (Cytoxan) Carboplatin (Paraplatin) Most often combination of two or three drugs is used. Advanced cancer-Patients with cancer which has spread beyond breast and lymph nodes can be given advanced chemotherapy treatment. Drugs used are- Docetaxel Paclitaxel Platinum agents (cisplatin, carboplatin) Vinorelbine (Navelbine) Capecitabine (Xeloda) Liposomal doxorubicin (Doxil) Gemcitabine (Gemzar) Mitoxantrone (Novantrone) Ixabepilone (Ixempra) Albumin-bound paclitaxel (nab-paclitaxel or Abraxane) Eribulin (Halaven) Hormone therapy: The therapy is used for cancers that are sensitive to the hormones. It blocks certain receptors to lower the cause of cancer. Drugs for such therapy are: Amoxifen - This drug blocks androgen receptor in breast cancer cells. It stops estrogen from binding to the cancer cells and help in dividing them. Side effects may include changes in periods, hot flashes, weight gain, headaches, nausea, vomiting, fatigue, and aching joints. Aromatase inhibitors - this type of medication may be offered to women who have been through the menopause. It blocks aromatase. Aromatase helps estrogen production after the menopause. Before the menopause, a woman's ovaries produce estrogen. Examples of aromatase inhibitors include letrozole, exemestane, and anastrozole. Side effects may include nausea, vomiting, fatigue, skin rashes, headaches, mood swings, bone pain, aching joints, loss of libido, sweats, and hot flashes. Targeted therapy- Trastuzumab (Herceptin) - this monoclonal antibody targets and destroys cancer cells that are HER2-positive. (HER2 is the gene that gets mutated in breast cancer). Possible side effects may include skin rashes, headaches, and/or heart damage. Lapatinib (Tykerb) - this drug targets the HER2 protein. It is also used for the treatment of advanced metastatic breast cancer. Tykerb is used on patients who did not respond well to Herceptin. Side effects include painful hands, painful feet, skin rashes, mouth sores, extreme tiredness, diarrhea, vomiting, and nausea. Breast cancer can be prevented by preventing all the certain risk factors which can increase the rate of this particular cancer.

Role of spirituality in shaping cancer patients lives

Spirituality is usually explained as an awareness of something greater than the individual self. It is often expressed in a prayer form, though there are different paths of spiritual pursuit and expression.

Spirituality is constitutional and a critical factor in the way cancer patients cope with their illness from diagnosis through treatment, survival, recurrence and dying. Studies have shown a beautiful blend between spirituality and quality of life. While cancer can trigger deep existential issues that could stimulate profound suffering and distress, spirituality will result in better health outcomes, particularly quality of life for patients across the course of cancer care.

Followers of spirituality in the context of health say that prayer can decrease the negative effects of disease, assist speedy recovery and augment the effectiveness of medical treatments. Attending religious events is connected with improvement of several health conditions such as heart disease, high blood pressure, stroke, cancers and overall health status. Scientists however have mixed evidence on this.

With spirituality, it’s easier to find meaning in life when dealing with cancer, even though it cannot cure the disease. Spirituality may also help us accept illness and death, both for ourselves and for loved ones.

How can spirituality be practiced?
Spirituality has multiple forms and can be practiced in various ways. Prayer is one form, which can be sung, spoken aloud or chanted. Regular attendance at a place of worship may involve prayer that focuses on one's self.

Spirituality can also be practiced with the help of meditation. Simple practices such as silent observation, listening, or gratefulness can become part of spirituality that can infuse everyday life. Some people like to spend time with nature, doing creative work, or serving others as part of spirituality.

Many medical professionals and practitioners support spirituality, prayer and meditation as important components of healing. Moreover, many hospitals have tied up with voluntary organizations to serve their patients’ spiritual needs.

Cancer patients need attention
The need to attend to the spiritual needs of cancer patients is well documented, both from the perspective of patient desire and the benefits to patients' quality of life. Not addressing spirituality could result in bleak prognosis, increased non-compliance with the treatment plan, and failure to help patients find effective coping mechanisms.

Studies indicate cancer patients' spiritual needs are under-addressed due to time constraints, lack of confidence in effectiveness, and role uncertainty. Other contributing factors include healthcare professional education and training, design of clinical practices, shortages of healthcare providers, and policy constraints.

Training in the recognition of spiritual needs is only one constituent of an effective model for the delivery of spiritual care. Screening for spiritual needs is not effective unless there is no effort to address these issues including supportive resources.

From the moment of diagnosis of cancer through treatment, cancer patients undergo immense distress. Spirituality can be a powerful positive force in helping patients reframe their illness, find greater meaning in life, and recognize what is ultimately important and of value to them. It is therefore responsibility of the medical professionals to address spiritual issues of the patient, diagnose and treat spiritual distress and integrate patients' spiritual resources of strength into the treatment plan. In this way, patients can receive the most compassionate care with improved quality of life as well as patient health outcomes.

Watch that peg! It might kill you

Do you drool over alcohol while enjoying the weekend party? Just think of this when you ponder over next time; alcohol is responsible for six deaths per minute across the globe! Shocked? Wondering what it can do to you? Alcohol kills because people get addicted and ring bells for other diseases such as cancer, violent behaviour, liver problems, injuries and more. The latest WHO report found that people consuming alcohol frequently are vulnerable to disorders like tuberculosis and pneumonia.

The quantity of alcohol consumption

Approximately, individuals (aged 15 or above) drink 6.2 litres of pure alcohol each year but since only 38.3% of the population actually drinks, those who are regular drinkers drink 17 litres per year. The study also revealed that men are likelier to die of alcohol addiction but women are more susceptible. Lower income group is most affected by the health hazards of alcohol consumption.

Where India Stands

Conventionally, India follows a non-drinking culture. However, in the last decade, the consumption has gone up with 32% men and 10% women above 15 drinking alcohol. The situation is worrisome in Delhi. As per a new survey, 64.6% girls and 83.8% boys in Delhi start drinking before age 18. Additionally, 11.1% boys and 2.1% girls spend around Rs.8000 on alcohol per month.

The survey was conducted among the youngsters of Delhi stated that 34.5% males and 28% females consume alcohol at least 2-4 times a week and 77% boys and 46% girls drink more than five glasses at one go.

India reports the highest number of road casualties (138,000) in the world and underage drinking attenuates the situation. The results showed 75% males and 12.3% females have indulged in drunken driving and none of them was ever asked about the age proof. It is high time the management takes stringent action.

How alcohol affects you?

Being high on calories, alcohol promotes weight gain and interferes with your fitness programme. There are some long term effects as well. Excessive alcohol impacts liver functionality and in worse case, damages it.

However, there’s light in the dark. If you want to rid yourself of excess alcohol consumption, always consult an experienced psychiatrist. 

Are We Responsible for Our Children’s Lack of Growth?

Children find themselves in precarious situation as society is fast adapting to reminiscent changes. Relationships and lifestyles are amended to fit in a new trend. It is the time when society’s old trends are paving way to newer ones. Eating habits too have drastically taken a makeover. We hardly see people having proper food. Instead they crave on what is popularly known as the JUNK FOOD. Junk food is anything that is tongue-twister, tasty, easy to make and in accordance with the latest trend. Every age group is in the grip of junk food and the latest to be mesmerised by its aura are new age children. Burgers, pizzas, chips and aerated drinks are suddenly the need of life. For instance, a child returning home from an arduous session at school suddenly pops in a bagful of chips and lay in front of the television. Don’t be shocked. It’s a common trend these days. Suddenly children have stepped into a whole new world of eateries that our ancestors wouldn’t have thought of.

The growing age for boys and girls vary. However, 6-12 years is considered to be steady time of growth. Top priority should be given to nutrition at this time. Children must understand what they eat is directly proportional to their behaviour, growth and over all development. Our society is revolutionised to such extend that it needs children to be educated upon the benefits of healthy eating. They need to be told how a balanced diet is essential for survival. Most of the working mothers are so much occupied with their corporate responsibilities that they tend to neglect the fact that their children actually need love and support. Conventional and more reliant food skills are not passed on automatically from parent to child. Most people just mug up food greatly undermining its nutritional effect. Since children are often glued to television sets, commercials and advertisements laced with promotional offers are the biggest culprits. We should be focusing more on structuring an atmosphere that pulls back our children from the claws of junk food.

Children who are unaware that consumption of junk food can lead to heart ailments, cancer, high BP or diabetes should not thrive on them knowingly. Studies have shown that clogging of arteries begin as early as 30 years and lay the foundation for future heart ailments. What children consume at early age affects their chances of prostate and breast cancer. Hypertension and Osteoporosis are other disorders that lay their roots in early childhood when lifelong eating habits are being shaped. Poor diets can affect growth, decompose new teeth, endorse obesity and sow the seeds of health issues that ultimately lead to non-treatable diseases.     

Most of the junk food is filled with artificial colours which are often unpalatable, carcinogenic and damaging to the body. These foods and their colouring can seriously damage digestive system, hamper immunity, the effects of which are seen when the children start to age. Results of surveys have proven that artificial colouring in junk food leads to hyperactivity and descending of attentiveness in children. Children distressing from learning disabilities are often counselled not to intake food with artificial colouring. Aerated drinks, chocolates, wafers all are laced with artificial colouring. 

Unsurprisingly, junk food not only has physical consequences but also mental ones- affecting a child’s psyche and personality. Smartly attending their dietary needs boosts their morale and exhilarates further unearthing. School days pose plenty of educational challenges requiring high level of concentrations and stamina. Poor eating habits can virtually sap children from participating in school events, indulging in games, interacting with family members or feeling confident about themselves.

Shamelessly, the traditional Indian diet that consists chapattis, pulses, rice, vegetables, upma have been replaced by pizzas, burgers, chowmein, spring rolls etc. Instead of having regular food, we are consuming what is considered by many dietitians as dangerous to the health. The comfort level you get after having a complete meal is predictably absent when we intake junk food. The question now arises who is to blame? Is it the society or we the parents who are pushing our children to adversity? The answer is both. Society trends have changed when it comes to choice of food. But in the end, it is our responsibility to educate our children on what is the right kind of food for them. We have to ensure that first; we have to set the trend so that they can carry the same to many more generations to come.